A "thumb break" is the retaining piece on the top of the holster that holds the gun in place as to not allow it to accidentally come out the top of your holster. It is usually disengaged via your thumb, hence thumb break, and allows you to draw the weapon from the holster. It is the traditional way to keep the gun in the holster. There are however a couple more modern designs that use alternate methods to keep the weapon in the holster (such as a blackhawk CQB serpa holster).
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