Comparing different offerings from the same company, the "degrees" is just the hardness of the rubber.
To lift heavier rounds at higher FPS, you'll need a less compliant rubber to impart the necessary backspin, thus the stiffer material. 50oo seems to be the rubber of choice for sub-400fps builds.
Although, I have run 50oo on one of my hardball guns to lift .3g BBs in the past and it worked out just fine.
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