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I'm left handed, used every pistol I've owned in 12 years with my left hand... and I've never run into an issue. Pistols are small enough that you can operate the controls with your left hand quite easily...
Only thing I've found that "doesn't work" is a target style pistol that's had the grip contoured to fit a right hand.
Right now I'm using a CZ P09 and I love the thing
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